In your body, TUDCA is created through a microbial process. Bile salts are released into your intestines through the liver’s bile duct. Then, the microbes in your gut metabolize the bile salts into ursodeoxycholic acid (UDCA). Later, it is connected to a taurine molecule to create TUDCA.
Bile Flow - TUDCA helps clear out whatever is blocking the flow of bile in the liver duct. Some studies show that taking TUDCA can help increase bile circulation by up to 250%! TUDCA increases bile release, but it also improves the quality of the bile itself, which directly benefits your liver cells. There is a greater amount of bile salts for the microbes in your intestines to create more of your own TUDCA.
Mitochondria in Liver Tissues - When the liver’s bile duct is blocked, the liver starts to die from the inside out at a cellular level. When the liver cannot remove its pollutants through the intestines, a massive amount of free radicals are produced in the liver cells. The mitochondria of these liver cells are attacked by all the reactive oxygen species. It makes it impossible for them to do their job of proper protein folding. Liver cells are programmed to die when they can no longer do their job efficiently. TUDCA helps maintain the proper folding process, reduces free radicals, and prevents programmed cell death of your liver cells.
Liver Enzymes - When your liver is under significant stress due to a blocked bile duct, your liver enzymes can significantly rise. Another benefit of TUDCA is the decrease of these liver enzymes. One study showed that even a modest dose of TUDCA lowered your liver enzymes in just two months.
Liver Bile Duct - Your liver releases ATP into bile when it is healthy. If your liver cells are dysfunctional, they cannot fill your bile with ATP, but TUDCA helps deliver ATP into the bile fluid. This is important because the ATP in bile gives your bile duct cells extra protection and prevents them from being damaged or scarred when the liver discharges dangerous chemicals that will be eliminated through your stool.
Intestines - If your hepatic bile duct is not functioning correctly, your intestinal function will be negatively affected. Your obstructed bile duct can lead to: intestinal inflammation, altered gene expression in the gut, a permeable gut, an altered gut microbiome, increased insulin resistance, damage, and loss of microvilli. TUDCA has been researched and shown to help resolve all these potential issues.
Additionally, certain medications can chemically alter bile flow, bile quality, and liver enzyme levels. TUDCA can significantly support your liver in these situations. We added choline to Tudca+ to further support liver function.
